Laboratoire Mixte International - “ Drug Resistance in South Asia”
  • Director: Dr. A.-L. Banuls (IRD) and Prof. Dang Duc Anh (NIHE)
  • Location: LMI DRISA is located on the campus of NIHE

1. History
This LMI (Laboratoire Mixte International) was set up and funded in 2016 by different Vietnamese and French partners, as well as partners from Laos, Cambodia and UK funded network.
Antibiotic resistance poses real problems in human and animal health worldwide, especially with the emergence of more and more resistant strains. South East Asia is the epicenter of many infectious diseases and also a major source of resistant and multidrug-resistant bacteria. In this alarming context, controlling their emergence and transmission has become a priority for all public health systems in this region.
Antibiotic resistance is probably the most common form of resistance and probably one of the most complex because of the particular characteristics of the bacterial biology. Antibacterial resistance may be encoded by one or more genes. It can occur by mutation and / or selection in a patient, following treatment (secondary resistance) or transmitted between patients (primary resistance). It may be vertically transmitted from one cell to another, by bacterial division or horizontally via a variety of mechanisms (between same species bacteria, or of different species). Besides these complex mechanisms at the cellular level, the spread of resistance occurs between diverse ecosystems characterized by different selection pressures (hospital and community settings, agricultural and urban environments ...). The knowledge of these evolutionary mechanisms is essential for the development of appropriate and efficient strategies to fight and control drug resistance.
2. Objectives
The purpose of the International Joint Laboratory DRISA is to get an overview of the mechanisms of drug resistance emergence and its transmission at different spatial and temporal scales. This will be achieved by developing complementary approaches involving (1) observational studies in hospital and community settings and in different environments, (2) experimental research, and (3) mathematical modeling.
Observational studies will collect data that are unfortunately still frequently lacking. They will also contribute to the characterization of transmission within and between the main compartments. Experimental studies will help understanding the molecular mechanisms of resistance and mathematical modeling will allow global analyzes of the data obtained but also to guide their collection and the experimental approaches. The models will also be used to explore and test hypotheses for which experimentation is impossible and to assist in the development of public health policies. In addition to research programs, the LMI will be strongly involved in both training and innovation.
Training will be provided as part of the teachings at the University of Science and Technology of Hanoi (USTH) and by the supervision of PhD and master students. Specific trainings will be also open to professionals. Innovation will aim to develop new technologies and diagnostic tools, as well as to study new antibacterial molecules.

3. Equipment

The laboratory is fully equipped for all molecular and cellular analysis of microorganisms as well as for growing pathogenic microorganisms in highly controlled and safe environments.

4. Partners

*) National Partners:
National Institute of Hygiene and Epidemiology (NIHE), Hanoi
University of Science and Technology of Hanoi (USTH)
Oxford University Clinical Research Unit (OUCRU), Hanoi

*) International Partners:
UMR MIVEGEC (IRD, CNRS, Montpellier University), France
Pasteur Institute Cambodia (IPC), Phnom Penh, Cambodia
Infectious Diseases Center Christophe Mérieux of Laos (CICML), Vientiane, Laos
Emerging Pathogens Laboratory (LPE), (Fondation Mérieux), Lyon, France

5. Team

*) Vietnamese Institutions researchers 
Dang Duc Anh, NIHE
Nguyen Thi Van Anh, NIHE
Tran Huy Hoang, NIHE
*) French Institutions researchers
Anne-Laure Banuls IRD, Mivegec
Marc Choisy, IRD, Mivegec
Jean-Luc Berland, LPE
Romain Gallet, BGPI
Samuel Alizon, Mivegec
Dorothée Missé, Mivegec
*) Other Institutions researchers
Heiman Wertheim, OUCRU