Dr. Le Thi Thu Hang

Qualifications

• 2008: Engineer of Biotechnology. Phuong Dong University, Hanoi
• 2012: Master of Biomedicine. University of Science and Technology, Hanoi/Aix-Marseille University, France
• 2017: Doctor of Structural Biochemistry. Aix-Marseille University, France

Research interests

The research works focus on two main directions. First, studies in medical microbiology and antimicrobial resistance, emphasizing genomic and plasmid analysis, virulence factors, and biofilm formation of pathogenic bacteria, thereby elucidating the mechanisms underlying the evolution and dissemination of multidrug resistance. Second, investigations into the discovery and evaluation of natural bioactive compounds, particularly those derived from plants and microorganisms, to assess their antibacterial and anticancer activities using both experimental and in silico approaches. These research directions contribute significantly to the development of strategies for infectious disease control and the identification of novel bioactive agents for biomedical applications.

Selected publications

1. Le, Thi Thu Hang, Christine Kellenberger, Marie Boyer, Pierre Santucci, Nicolas Flaugnatti, Eric Cascales, Alain Roussel, Stéphane Canaan, Laure Journet, and Christian Cambillau. 2023. “Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model” International Journal of Molecular Sciences 24, no. 2: 1740. https://doi.org/10.3390/ijms24021740
2. Nguyen QH, Le TTH, Nguyen ST, Nguyen K-OT, Quyen DV, Hayer J, Bañuls A-L and Tran TTT (2023) Large-scale analysis of putative plasmids in clinical multidrug-resistant Escherichia coli isolates from Vietnamese patients. Front. Microbiol. 14:1094119. doi: 10.3389/fmicb.2023.1094119
3. Hang LTT, Huy NQ, Tam TTT, Huong LT, Nam PH, Dang NH, Quyet-Tien P, Trang DT, Yang SY, Tai BH. Four new N-phenethylbenzamide derivatives from the stems of piper betle and their antimicrobial activity. Nat Prod Res. 2023 Jun;37(12):1969-1977. doi: 10.1080/14786419.2022.2114473. Epub 2022 Aug 22. PMID: 35994376.
4. Nguyen QH, Nguyen CL, Nguyen TS, Do BN, Tran TTT, Le TTH, Bui TT, Le HS, Quyen DV, Hayer J, Bañuls AL, Bui TS. Genomic insights into an extensively drug-resistant and hypervirulent Burkholderia dolosa N149 isolate of a novel sequence type (ST2237) from a Vietnamese patient hospitalised for stroke. J Glob Antimicrob Resist. 2024 Jun;37:44-47. doi: 10.1016/j.jgar.2024.02.009. Epub 2024 Feb 24. PMID: 38408562.
5. Commans, F., Hayer, J., Do, B.N. et al. Whole-genome sequence and resistance determinants of four Elizabethkingia anophelis clinical isolates collected in Hanoi, Vietnam. Sci Rep 14, 7241 (2024). https://doi.org/10.1038/s41598-024-57564-3
6. Le, Thanh Huong, Quang Huy Nguyen, Thu Thi Hien Le, Hoang Long Le, Quang Hieu Pham, Kieu Oanh Thi Nguyen, Hoang Nam Pham, Thanh Hoa Tran, Tan Khanh Nguyen, Manh Hung Tran and Hai Dang Nguyen. “Cytotoxic Activity of Vietnamese Morus alba Leaf Compounds Against Human Leukemia Cells: In Vitro and In Silico Evaluations.” Revista Brasileira de Farmacognosia 35 (2025): 968 – 980.
7. Nhung PTT, Le HTT, Nguyen QH, Huyen DT, Quyen DV, Song LH, Van Thuan T and Tran TTT (2024) Identifying fecal microbiota signatures of colorectal cancer in a Vietnamese cohort. Front. Microbiol. 15:1388740. doi: 10.3389/fmicb.2024.1388740
8. Tran Hoang Son, Vu Dinh Quang, Nguyen Dang Quang, Bui Duc Thinh, Do Thu Uyen, Le Thi Thu Hang, Tran Thi Thanh Tam, Pham Hoang Nam, Nguyen Kim Hanh, Hoang Trung Du, Bañuls Anne-Laure, Pulliat Gwenn, Théry Sylvain, Bettarel Yvan, Auguet Jean-Christophe, Nguyen Quang Huy (2025). Occurrence of multidrug-resistant Enterobacteriaceae and antibiotic-resistant genes in the anthropogenic impacted bay of Nha Trang, Viet Nam. Regional Studies In Marine Science. 83. 104084 (9p.). https://doi.org/10.1016/j.rsma.2025.104084, https://archimer.ifremer.fr/doc/00942/105354/
9. Bui TT, Tran TTT, Nguyen TS, Le TTH, Nguyen CL, Pham HN, Bañuls AL, Le HS, Le HPA, Bui TT, Bui TS, Phan QH, Tran THT, Nguyen QH. Genomic insights into virulence, biofilm formation, and antimicrobial resistance of multidrug-resistant Helicobacter pylori strains of novel sequence types isolated from Vietnamese patients with gastric diseases. J Glob Antimicrob Resist. 2025 Jun;43:237-241. doi: 10.1016/j.jgar.2025.05.001. Epub 2025 May 8. PMID: 40345333.
10. Ngo, Cao Cuong, Quang Huy Nguyen, Thu Hoai Nguyen, Ngoc Tung Quach, Pravin Dudhagara, Thi Hanh Nguyen Vu, Thi Thanh Xuan Le, Thi Thu Hang Le, Thi Thu Hong Do, Van Duc Nguyen, and et al. 2021. “Identification of Fungal Community Associated with Deterioration of Optical Observation Instruments of Museums in Northern Vietnam” Applied Sciences 11, no. 12: 5351. https://doi.org/10.3390/app11125351
11. Quach NT, Nguyen QH, Vu THN, Le TTH, Ta TTT, Nguyen TD, Van Doan T, Van Nguyen T, Dang TT, Nguyen XC, Chu HH, Phi QT. Plant-derived bioactive compounds produced by Streptomyces variabilis LCP18 associated with Litsea cubeba (Lour.) Pers as potential target to combat human pathogenic bacteria and human cancer cell lines. Braz J Microbiol. 2021 Sep;52(3):1215-1224. doi: 10.1007/s42770-021-00510-6. Epub 2021 May 1. PMID: 33934292; PMCID: PMC8324668.

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ORCID ID	https://orcid.org/0000-0001-8313-3527
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Research Gate	https://www.researchgate.net/profile/Thi-Le-6?ev=hdr_xprf