Assoc. Prof. Nguyen Thi Kieu Oanh

Qualifications

• 2023: Associate Professor, Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam
• 2020: Deputy Director of Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam
• 2018: Visiting Researcher in RIKEN, Japan
• 2015: Visiting Researcher in Department of Biology, University of York, United Kingdom
• 2014: Lecturer, Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam
• 2013: PhD in Plant biology. University of Picardie Jules Verne Amiens, France
• 2009: Pharmacist Degree in General Pharmacy. Hanoi University of Pharmacy

Research interests

My expertise lies in developing pipelines for comprehensive metabolomics analysis and its applications in the life sciences. The pipeline covers small-molecule extraction, derivatization, and chromatographic separation (liquid and gas chromatography), along with detection methods based on mass spectrometry. It also integrates computational tools for processing complex metabolomics data and building correlation networks, multivariate analysis, and molecular networking to investigate metabolic processes at multiple biological levels—from cells, tissues, and whole organisms to plant, microbiota and clinical samples. These efforts aim to elucidate biosynthetic pathways of bioactive natural products and identify biomarkers that support drug discovery and early diagnostics.

Selected publications

1. Van Hung Hoang, Thi Thanh Huong Le, Thi Tam Khieu, Thi Ngoc Thuy Le, Thi Kieu Oanh Nguyen, Phu Hung Nguyen (2025). Trevesia palmata-derived terpenoid-rich silver nanoparticles induce apoptosis and upregulate p21/CAV1 proteins in gastric cancer cells. RSC Advances, 32. (Q1 journal)
2. Nguyen, P. N., Dao, Y.V., Dang, K. P., Nguyen, T. N. H., Pham, M. Q., Nguyen, N. L, Pham, H.N., Sylvie N., Dijoux Franca, M. G, Nguyen, T. K. O (2025). Flavonoids from Pteris vittata L. EnhanceAntibiotic Sensitivity to Multidrug-Resistant Stenotrophomonas maltophilia. ChemistrySelect
3. Nguyen, P. H., Hoang, V. H., Nguyen, T. K. O., Khieu, T. T., Le, T. N. T., Trinh, T. H., Mong, T. L., Le, T. N., & Le, T. T. H. (2025). Biogenic silver nanoparticles from Croton tonkinensis extract: Inhibition of gastric cancer cells via cell cycle arrest and ROS-mediated apoptosis. Journal of Agriculture and Food Research, 23, 102171. (Q1 journal)
4. Le, T.H., Nguyen, Q.H., Le, T.H.T, Le, H.L, Pham Q.H, Nguyen, T.K.O, Pham, H.N, Tran, T.H, Nguyen, T.K., Tran, M.H., Nguyen, H.D. Cytotoxic Activity of Vietnamese Morus alba Leaf Compounds Against Human Leukemia Cells: In Vitro and In Silico Evaluations. Rev. Bras. Farmacogn. 35, 968–980 (2025).
5. Nguyen, T.N., Trieu, H.P., Nguyen, T.C., Do, T.P, Le, H.N.H., Tran, L.N.K, Chu, H.H., Nguyen, T.N, Pham, V.C., Nguyen, T.K.O, Do, T.T. Stemness reducible effects of glyasperin A against NCCIT teratocarcinomas. Naunyn-Schmiedeberg’s Arch Pharmacol (2025). (Q1 journal).
6. Van Hung Hoang, Thi Kieu Oanh Nguyen, Phu Hung Nguyen, Thi Thanh Huong Le, Viet Hoang (2025). Chemical composition and anticancer activity of Psychotria montana on MCF7 breast cancer cells: insights from in vitro (2D & 3D) studies and in silico analysis. Journal of Applied Biomedicine (Q1 journal).
7. Kieu‐Oanh Nguyen Thi, Ngoc‐Lien Nguyen, Khanh‐Phuong Dang, Phuong‐Nhung Nguyen, Huyen‐Thu Nguyen Thi, Hoang‐Nam Pham, Sylvie Nazaret, Marie‐Geneviève Dijoux‐Franca (2025). Identification of Antibacterial Agents with a Synergistic Effect in Pteris vittata L. by Exploration of Metabolome Data and Multivariate Analysis. Phytochemical analysis.
8. Nguyen Phuong Nhung, Nguyen Ngoc Lien, Pham Hai Nam, Nguyen Phuong Khanh, Nguyen Thi Kieu Oanh (2025). Antioxidant and antibacterial activities of Pteris vittata L. extracts from metalliferous soils: correlations with phenolic compounds. Natural product communications.
9. Thi Thanh Huong Le, Dinh Quang Hung Can, Thi Ngoc Thuy Le, Viet Hoang, Hong Phuong Ngo, Thi Thu Huyen Do, Kieu Oanh Nguyen Thi, Van hung Hoang, Nguyen Phu Hung (2025). Anticancer Potential of Ampelopsis cantoniensis Extract: Inducing Apoptosis, Cell Cycle Arrest, and Targeting Cancer Stem Cells in HepG2 Liver Cancer Cells. Biocatalysis and Agricultural Biotechnology (Q1 journal).
10. June-Sik Kim, Muneo Sato, Mikiko Kojima, Muchamad Imam Asrori, Yukiko Uehara-Yamaguchi, Yumiko Takebayashi, Thi Nhung Do, Thi Yen Do, Kieu Oanh Nguyen Thi, Hitoshi Sakakibara, Keiichi Mochida, Shinjiro Ogita & Masami Yokota Hirai (2025). Multiomics-based assessment of the impact of airflow on diverse plant callus cultures. Scientific data (Q1 journal)
11. Van Hung Hoang, Thi Thanh Huong Le, Phu Hung Nguyen, Viet Hoang, Van Khang Pham, Thi Kieu Oanh Nguyen, Dinh Quang Hung Can (2024). Acorus gramineus extract decreases cancer stem cell properties and stimulates ROS signaling pathway in HepG2 hepatocellular carcinoma cells. Pharmacological Research – Modern Chinese Medicine
12. June-Sik Kim, Muneo Sato, Mikiko Kojima, Muchamad Imam Asrori, Yukiko Uehara-Yamaguchi, Yumiko Takebayashi, Thi Nhung Do, Thi Yen Do, Kieu Oanh Nguyen Thi, Hitoshi Sakakibara, Keiichi Mochida, Shijiro Ogita, Masami Yokota Hirai (2024). Multi-omics signatures of diverse plant callus cultures. Plant Biotechnology 41, 1-6
13. Nguyen, P. N., Le, H. L., Gontier, E., Hoang Thi, H. C., Le Thi, V. A., Mai Thi, P. N., & Nguyen T., K.O. A Comprehensive Strategy for Metabolites Profiling of Flowers and Leaves from Camellia tienii, an Endemic Golden Tea of Vietnam. Chemistry & Biodiversity, e202400997.
14. Nguyen Phuong Nhi, Do Thi Yen, Do Thi Nhung, Eric Gontier, Le Nguyen Ha Trang, Le Thi Van Anh, Nga T.P. Mai, Muneo Sato, Masami Yokota Hirai, Nguyen Thi Kieu Oanh (2024). Widely targeted metabolomics reveals the species-specific, matureness-specific and postharvest-specific discriminations in the chemical profiles of Vietnamese endemic golden camellias. International Journal of Food Science & Technology. (Q1 journal)
15. Uyen Thi Tu Phan, Hai Dang Nguyen, Thi Kieu Oanh Nguyen, Tuan Hiep Tran, Thanh Huong Le, Thi Thu Phuong Tran (2024). Anti-inflammatory effect of Piper longum L. fruit methanolic extract on lipopolysaccharide-treated RAW 264.7 murine macrophages. Heliyon. (Q1 journal)
16. Magdalena Osial, Sławomir Wilczewski, Joanna Szulc, Hai Dang Nguyen, Thi Kieu Oanh Nguyen, Katarzyna Skórczewska, Agnieszka Majkowska-Pilip, Kinga Żelechowska-Matysiak, Dorota Nieciecka, Agnieszka Pregowska, Phuong Thu Nguyen, Alicja Tymoszuk, Dariusz Kulus, Michael Giersig (2023). Nanohydroxyapatite Loaded with 5-Fluorouracil and Calendula officinalis L. Plant Extract Rich in Myo-Inositols for Treatment of Ovarian Cancer Cells. Coatings
17. Kieu Oanh Thi Nguyen, Nhung Do Thi, Khanh Phuong Dang, Muneo Sato, Masami Yokota Hirai (2023). Single-grain-based widely targeted metabolomics profiling of sixty-four accessions of Japanese wild soybean (Glycin soja Sieb. Et Zucc.). International Journal of Food Science & Technology. (Q1 journal)
18. Quang Huy Nguyen, Thi Thu Hang Le, Son Thai Nguyen, Kieu-Oanh Thi Nguyen, Dong Van Quyen, Juliette Hayer, Anne-Laure Bañuls and Tam Thi Thanh Tran (2023). Meta-analysis of putative plasmids in clinical multidrug-resistant Escherichia coli isolates from Vietnamese patients. Frontiers in microbiology. 14, 1640 (Q1 journal)
19. Van Phuong Nguyen, Thi Van Anh Le, Huong Thi Mai To, Thi Kieu Oanh Nguyen, Nga T.P. Mai (2023). Systemic adaptation of rice plants under low phosphate conditions. Italian journal of agronomy. 18, 2181
20. Trinh Hoang Nghia, Vu Toan Khanh, Cam Tu Vu, Nguyen Thi Kieu Oanh, Nguyen Thi Van Anh, Le Hong Luyen, Nobuaki Negishi, Sylvain Ouillon and Bui Van Hoi (2023). Removal of carbamazepine in aqueous solution by TiO2 ceramic photo-catalyst under simulated solar light: kinetics, effects of environmental factors and degradation pathways. Water. 15, 8, 1583 (Q1 journal)
21. Thi Huyen Thu Nguyen, Hai Dang Nguyen, Mai Huong Le, Thi Thu Hien Nguyen, Thi Dua Nguyen, Duc Long Nguyen, Quang Huy Nguyen, Thi Kieu Oanh Nguyen, Serge Michalet, Marie-Geneviève Dijoux-Franca and Hoang Nam Pham (2023). Efflux pump inhibitors in controlling antibiotic resistance: Outlook under a heavy metal contamination context. Molecules. 28, 7, 2912
22. Pia Fahmé, Farah Ramadan, Diep Tien Le, Kieu-Oanh Nguyen Thi, Sandra E Ghayad, Nader Hussein, Chantal Diaz, Martine Croset, Philippe Clézardin, Pascale A Cohen (2022). The intricate interplay between the ZNF217 oncogene and epigenetic processes shapes tumor progression. Cancers. 14, 24, 6043
23. T. Van Anh Le, T.P. Mai Nga, P. Nhi Nguyen, T. Kieu Oanh Nguyen (2023). Genotypic and phenotypic diversity of endemic Golden Camellias collected from the North of Vietnam. Chemistry & biodiversity. 20, 1, e202200843
24. Phuong Nhung Nguyen, Kieu Oanh Nguyen T., Dinh Quang Tran, The Hai Pham (2023) Prediction of cytotoxicity against HepG2 by quantitative structure-activity relation (QSAR) modelling. Trends in sciences. 20, 7, 5388
25. Kieu-Oanh Nguyen Thi, Phuong Linh Nguyen, Huyen Thao Le, Hoang Long Le. Discriminative chemical profiles of Shan Tuyet tea (Camellia sinensis var. Shan) and Sinensis tea (Camellia sinensis var. sinensis) collected in Ta Xua, Son La, Vietnam and their correlation with antioxidant activity. Natural product communications, 17, 9, 1-9
26. Ngoc-Lien Nguyen, Van-Hoi Bui, Hoang-Nam Pham, Hien-Minh To, Marie-Geneviève Dijoux-Franca, Cam-Tu Vu, Kieu-Oanh Thi Nguyen (2022). Ionomics and metabolomics analysis reveal the molecular mechanism of metal tolerance of Pteris vittata L. dominating in a mining site of Thai Nguyen province, Vietnam. Environmental science and pollution research. 29, 58, 87268-87280 (Q1 journal)
27. Kieu-Oanh Nguyen Thi, Thanh-Huong Le, Hai-Dang Nguyen, Quang-Huy Nguyen, Thi-Yen Do, Thi-Phuong-Nga Mai & Thi-Van-Anh Le (2022) Phytochemical Composition and Potential Bioactivities of the Essential Oil from the Peels of Paramignya trimera (Oliv.) Guillaum from Vietnam, Journal of Essential Oil Bearing Plants, 25:2, 273-281
28. Nguyen Thi K-O, Do H-G, Duong N-T, Nguyen TD, Nguyen Q-T (2021). Geographical Discrimination of Curcuma longa L. in Vietnam Based on LC-HRMS Metabolomics. Natural Product Communications. 16, 10, 1-10. doi:10.1177/1934578X211045479
29. Nguyen Thi KO, Nguyen NL, Pham HN, Sawada Y, Hirai MY, Dauwe R, Dijoux-Franca MG (2021). Development of a Pteris vittata L. compound database by widely targeted metabolomics profiling. Biomedical Chromatography. 35(8):e5110. doi: 10.1002/bmc.5110. Epub 2021 Mar 26. PMID: 33675049.

For further information:

ORCID ID	https://orcid.org/0000-0002-3548-8339
Google Scholar	https://scholar.google.com/citations?user=jkJb3-kAAAAJ&hl=en
Research Gate	https://www.researchgate.net/profile/Nguyen-Kieu-Oanh-2