Assoc. Prof. Nguyen Thi Kieu Oanh

Qualifications

• 2023: Associate Professor, Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam
• 2020: Deputy Director of Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam
• 2018: Visiting Researcher in RIKEN, Japan
• 2015: Visiting Researcher in Department of Biology, University of York, United Kingdom
• 2014: Lecturer, Department of Life Sciences, University of Science and Technology of Hanoi, Vietnam
• 2013: PhD in Plant biology. University of Picardie Jules Verne Amiens, France
• 2009: Pharmacist Degree in General Pharmacy. Hanoi University of Pharmacy

Research interests

• Plant metabolomics: Small molecule extraction, isolation and derivatization, chromatographic separation, detection by mass spectrometry and use algorithms in R to facilitate mining complex metabolomics data and employed correlation networks, multivariate analysis, and molecular networking to identify active natural products, ensure the quality control of herbal medicines, and understand metabolic pathway responses to changing environments.
• Natural product-based drug discovery: extraction, isolation of natural compounds, followed by in-vitro, in-vivo bioassays.

Selected publications

1. Nguyen Phuong Nhi, Do Thi Yen, Do Thi Nhung, Eric Gontier, Le Nguyen Ha Trang, Le Thi Van Anh, Nga T.P. Mai, Muneo Sato, Masami Yokota Hirai, Nguyen Thi Kieu Oanh (2024). Widely targeted metabolomics reveals the species-specific, matureness-specific and postharvest-specific discriminations in the chemical profiles of Vietnamese endemic golden camellias. International Journal of Food Science & Technology.
2. Uyen Thi Tu Phan, Hai Dăng Nguyen, Thi Kieu Oanh Nguyen, Tuan Hiep Tran, Thanh Huong Le, Thi Thu Phuong Tran (2024). Anti-inflammatory effect of Piper longum fruit methanolic extract on lipopolysaccharide-treated RAW 264.7 murine macrophages. Heliyon.
3. Magdalena Osial, Sławomir Wilczewski, Joanna Szulc, Hai Dang Nguyen, Thi Kieu Oanh Nguyen, Katarzyna Skórczewska, Agnieszka Majkowska-Pilip, Kinga Żelechowska-Matysiak, Dorota Nieciecka, Agnieszka Pregowska, Phuong Thu Nguyen, Alicja Tymoszuk, Dariusz Kulus, Michael Giersig (2023). Nanohydroxyapatite Loaded with 5-Fluorouracil and Calendula officinalis L. Plant Extract Rich in Myo-Inositols for Treatment of Ovarian Cancer Cells. Coatings
4. Kieu Oanh Thi Nguyen, Nhung Do Thi, Khanh Phuong Dang, Muneo Sato, Masami Yokota Hirai (2023). Single-grain-based widely targeted metabolomics profiling of sixty-four accessions of Japanese wild soybean (Glycin soja Sieb. Et Zucc.). International Journal of Food Science & Technology.
5. Quang Huy Nguyen, Thi Thu Hang Le, Son Thai Nguyen, Kieu-Oanh Thi Nguyen, Dong Van Quyen, Juliette Hayer, Anne-Laure Bañuls and Tam Thi Thanh Tran (2023). Meta-analysis of putative plasmids in clinical multidrug-resistant Escherichia coli isolates from Vietnamese patients. Frontiers in microbiology. 14, 1640
6. Van Phuong Nguyen, Thi Van Anh Le, Huong Thi Mai To, Thi Kieu Oanh Nguyen, Nga T.P. Mai (2023). Systemic adaptation of rice plants under low phosphate conditions. Italian journal of agronomy. 18, 2181
7. Trinh Hoang Nghia, Vu Toan Khanh, Cam Tu Vu, Nguyen Thi Kieu Oanh, Nguyen Thi Van Anh, Le Hong Luyen, Nobuaki Negishi, Sylvain Ouillon and Bui Van Hoi (2023). Removal of carbamazepine in aqueous solution by TiO2 ceramic photo-catalyst under simulated solar light: kinetics, effects of environmental factors and degradation pathways. Water. 15, 8, 1583
8. Thi Huyen Thu Nguyen, Hai Dang Nguyen, Mai Huong Le, Thi Thu Hien Nguyen, Thi Dua Nguyen, Duc Long Nguyen, Quang Huy Nguyen, Thi Kieu Oanh Nguyen, Serge Michalet, Marie-Geneviève Dijoux-Franca and Hoang Nam Pham (2023). Efflux pump inhibitors in controlling antibiotic resistance: Outlook under a heavy metal contamination context. Molecules. 28, 7, 2912
9. Pia Fahmé, Farah Ramadan, Diep Tien Le, Kieu-Oanh Nguyen Thi, Sandra E Ghayad, Nader Hussein, Chantal Diaz, Martine Croset, Philippe Clézardin, Pascale A Cohen (2022). The intricate interplay between the ZNF217 oncogene and epigenetic processes shapes tumor progression. Cancers. 14, 24, 6043
10. Van Anh Le, T.P. Mai Nga, P. Nhi Nguyen, T. Kieu Oanh Nguyen (2023). Genotypic and phenotypic diversity of endemic Golden Camellias collected from the North of Vietnam. Chemistry & biodiversity. 20, 1, e202200843
11. Phuong Nhung Nguyen, Kieu Oanh Nguyen T., Dinh Quang Tran, The Hai Pham (2023) Prediction of cytotoxicity against HepG2 by quantitative structure-activity relation (QSAR) modelling. Trends in sciences. 20, 7, 5388
12. Kieu-Oanh Nguyen Thi, Phuong Linh Nguyen, Huyen Thao Le, Hoang Long Le. Discriminative chemical profiles of Shan Tuyet tea (Camellia sinensis var. Shan) and Sinensis tea (Camellia sinensis var. sinensis) collected in Ta Xua, Son La, Vietnam and their correlation with antioxidant activity. Natural product communications, 17, 9, 1-9
13. Ngoc-Lien Nguyen, Van-Hoi Bui, Hoang-Nam Pham, Hien-Minh To, Marie-Geneviève Dijoux-Franca, Cam-Tu Vu, Kieu-Oanh Thi Nguyen (2022). Ionomics and metabolomics analysis reveal the molecular mechanism of metal tolerance of Pteris vittata dominating in a mining site of Thai Nguyen province, Vietnam. Environmental science and pollution research. 29, 58, 87268-87280
14. Kieu-Oanh Nguyen Thi, Thanh-Huong Le, Hai-Dang Nguyen, Quang-Huy Nguyen, Thi-Yen Do, Thi-Phuong-Nga Mai & Thi-Van-Anh Le (2022) Phytochemical Composition and Potential Bioactivities of the Essential Oil from the Peels of Paramignya trimera (Oliv.) Guillaum from Vietnam, Journal of Essential Oil Bearing Plants, 25:2, 273-281
15. Nguyen Thi K-O, Do H-G, Duong N-T, Nguyen TD, Nguyen Q-T (2021). Geographical Discrimination of Curcuma longa in Vietnam Based on LC-HRMS Metabolomics. Natural Product Communications. 16, 10, 1-10. doi:10.1177/1934578X211045479
16. Nguyen Thi KO, Nguyen NL, Pham HN, Sawada Y, Hirai MY, Dauwe R, Dijoux-Franca MG (2021). Development of a Pteris vittata compound database by widely targeted metabolomics profiling. Biomedical Chromatography. 35(8):e5110. doi: 10.1002/bmc.5110. Epub 2021 Mar 26. PMID: 33675049.
17. Thi Kieu Oanh Nguyen, Paulo Marcelo, Eric Gontier, Rebecca Dauwe (2019). Metabolic markers for the yield of lipophilic indole alkaloids in dried woad leaves (Isatis tinctoria L.). Phytochemistry. 2019, 163: 89-98
18. Thi Dao Vu, Cyril Jousse, Nathalie Pawlicki-Jullian, Séverine Schiltz, Thi Kieu Oanh Nguyen, Thi Le Minh Tran, Laure-Anne Bouquet, Alain Hehn, Michèle Boitel-Conti, Julie Moussaron, Flore Biteau, Corinne Assaf-Ducrocq, Christophe Robin, Frédéric Bourgaud, Armand Guckert, Eric Gontier (2018) Datura innoxia plants hydroponically-inoculated with Agrobacterium rhizogenes display an enhanced growth and alkaloid metabolism. Plant Science. 277, 166-176
19. Hoang Nam Pham, Serge Michalet, Josselin Bodillis, Tien Dat Nguyen, Thi Kieu Oanh Nguyen, Thi Phuong Quynh Le, Mohamed Haddad, Sylvie Nazaret & Marie-Geneviève Dijoux-Franca (2017) Impact of metal stress on the production of secondary metabolites in Pteris vittata and associated rhizosphere bacterial communities. Environmental science and pollution research. 24, 16735-16750
20. Nguyen T. Kieu Oanh, Arash Jamali, Eric Grand, Kris Morreel, Paulo Marcelo, Eric Gontier, Rebecca Dauwe (2017) Phenylpropanoid profiling reveals a class of Hydroxycinnamoyl glucaric acid conjugates in Isatis tinctoria leaves. Phytochemistry. 144: 127-140
21. Nguyen, T. Kieu Oanh, Lanoue, A., Dauwe, R., Gontier, E. (2015) Unraveling the biochemical mechanism underlying increased hyoscyamine levels in Agrobacterium rhizogenes induced hairy roots of Datura innoxia. Phytochemistry. 116: 94-103
22. Nguyen, T.K.O., Dauwe, R., Bourgaud, F.& Gontier, E (2013). From bioreactor to entire plants: development of production systems for secondary metabolites; In Advances in Botanical Research; Ed. Guivarc’h; Biosynthesis of Alkaloids in Plants, Chapter 9: Bioengineering of alkaloid production in plant. Advances in Botanical Research. 68:205-230