Dr. Le Thanh Huong

Qualifications

• 2011: Bachelor in Biology. Hanoi University of Science, Vietnam National University
• 2013: Master in Biotechnology. University of Science and Technology of Hanoi
• 2018: Ph.D. in Pathology, Toxicology, Genetics, and Nutrition, Paul Sabatier University, France

Research interests

• Evaluation of biological activities and pharmacological properties of natural compounds
• Mechanistic studies of key activities:
• Cytotoxic (anticancer) effects
• Anti-inflammatory effects
• Inhibition of osteoclastogenesis (anti-osteoporotic)
• Close integration with natural product isolation studies
• Bridging natural product chemistry and drug discovery efforts

Selected publications

1. Le Thanh Huong, Vu Duong Bach, Pham The Hai, Vu Mai Thao, Nguyen Xuan Nhiem, Nguyen Hai Dang*, Cycloartane-type saponins from Curculigo orchioides and their anti-inflammatory activity, RSC Advances, 15, 41340-41350, 2025.
2. Thanh Huong Le, Quang Huy Nguyen, Thu Hang Thi Le, Hoang Long Le, Quang Hieu Pham, Kieo Oanh Thi Nguyen, Hoang Nam Pham, Thanh Hoa Tran, Tan Khanh Nguyen, Manh Hung Tran, Hai Dang Nguyen*. Cytotoxic activity of Vietnamese Morus alba leaf compounds against human leukemia cells: In vitro and in silico evaluations. Rev. Bras. Farmacogn. 35, 968–980, 2025.
3. Tran TH, Le TH, Tran TTP. The potential effect of endogenous antimicrobial peptides in cancer immunotherapy and prevention. Journal of Peptide Science, 2025, 31(2): e3664.
4. Nguyen, T. Q., Nguyen, D. H., Phan, U. T. T., Tran, P. T. T., LE, H. T., Nguyen, S. H., Nguyen, J., Han, B. O., & Hoang, B. X. (2024). Fenbendazole and Diisopropylamine Dichloroacetate Exert Synergistic Anti-cancer Effects by Inducing Apoptosis and Arresting the Cell Cycle in A549 Lung Cancer Cells. Anticancer research, 44(11), 4761–4772. https://doi.org/10.21873/anticanres.17302
5. Phan UTT, Nguyen HD, Nguyen TKO, Tran TH, Le TH, Tran TTP. Anti-inflammatory effect of Piper longum L. fruit methanolic extract on lipopolysaccharide-treated RAW 264.7 murine macrophages. Heliyon, 2024, 10(4).
6. Tran TT Phuong, Nhiem NX, Pham-The H, Phan UTT, Huong LT. Alkaloids from Piper longum L. and their anti-inflammatory properties. Chemistry & Biodiversity, 2024, 21(12): e202401224.
7. Nguyen TQ, Nguyen DH, Phan UTT, Tran PTT, Le HT, Nguyen SH. Fenbendazole and diisopropylamine dichloroacetate exert synergistic anti-cancer effects by inducing apoptosis and arresting the cell cycle in A549 lung cancer cells. Anticancer Research, 2024, 44(11): 4761–4772.
8. Tran TTP, Trang DT, Huong LT, Giap TH, Hang NTM. Chemical Constituents from Memecylon scutellatum with Nitric Oxide Inhibitory Activity. Natural Product Communications, 2024, 19(12): 1934578X241304173.
9. Huong LT, Anh TT, Hang NM, Thao VM, Nhiem NX, Dang NH. Stereochemical assignment of four monoterpene glucoside derivatives from Turpinia montana Kurz by NMR study combined with CD spectroscopy. Magnetic Resonance in Chemistry, 2024, 62(8).
10. Hang LTT, Huy NQ, Tam TTT, Huong LT, Nam PH, Dang NH. Four new N-phenethylbenzamide derivatives from the stems of Piper betle and their antimicrobial activity. Natural Product Research, 2023, 37(12): 1969–1977.
11. Gal M, Kim O, Tran PT, Huong LT, Nhiem NX, Kiem PV, Dang NH. Mussaendoside O, a N-triterpene cycloartane saponin, attenuates RANKL-induced osteoclastogenesis and inhibits lipopolysaccharide-induced bone loss. Phytomedicine, 2022, 105: 154378.
12. Gal M, Kim O, Tran PT, Nhiem NX, Kiem PV, Minh CV, Dang NH. 23-Hydroxyursolic acid from Viburnum lutescens inhibits osteoclast differentiation in vitro and lipopolysaccharide-induced bone loss in vivo by suppressing c-Fos and NF-κB. International Immunopharmacology, 2022, 111: 109038.
13. Nguyen KO, Le TH, Nguyen HD, Nguyen QH, Do TY, Mai TPN. Phytochemical composition and potential bioactivities of the essential oil from the peels of Paramignya trimera (Oliv.) Guill. from Vietnam. Journal of Essential Oil Bearing Plants, 2022, 25(2): 273–281.
14. Huong LT, Thao TP, Trang DT, Lee JH, Tai BH, Kiem PV, Nhiem NX. Anti-osteoclastogenic cycloartane saponins from Mussaenda pubescens. Natural Product Research, 2021, 36(18): 4591–4598.
15. Seo W, Lee S, Tran PT, Ngo TQM, Kim O, Le TH, Dang NH, Hwangbo C. 3-Hydroxyolean-12-en-27-oic acids inhibit RANKL-induced osteoclastogenesis in vitro and inflammation-induced bone loss in vivo. International Journal of Molecular Sciences, 2021, 21(15): 5240.
16. Huong LT, Thu PA, Son NH, Dang NH. Anti-inflammatory properties of Amomum maximum Roxb and Amomum muricarpum Elmer in the North of Vietnam. Vietnam Journal of Biotechnology, 2021, 19(2): 301–307.
17. Trang DT, Dang NH. Screening for Vietnamese plant extracts with potential benefit for anti osteoclastogenesis. Vietnam Journal of Science and Technology, 2021, 59(4): 507–517.
18. Le TH, Duong TT, Tran PT, Pham VC, Nguyen HD, Lee JH. Anti-osteoclastogenesis potential agents from plants naturalized in Vietnam. Pharmacognosy Magazine, 2021, 17(75): 525–525.

For further publications of Dr. Le Thanh Huong, please read below:

ORCID ID

https://orcid.org/my-orcid?orcid=0000-0002-7628-4674