Qualifications
2013: Doctor in Natural Science, Friedrich-Schiller University Jena, Jena, Germany
Teaching interests
Drug development and medicinal chemistry
Research interests
Our research focuses on evaluating the biological activities and underlying pharmacological mechanisms of natural compounds derived from terrestrial plants and marine organisms. The core expertise involves investigating the mechanisms of cytotoxic (anti-cancer), anti-inflammatory, and anti-osteoclastogenic (anti-osteoporosis) activities. By applying these specialized biological and cellular assays, this work complements chemical isolation efforts and serves as a crucial bridge connecting natural product chemistry with modern drug development.
Selected publications
- Le Thanh Huong, Vu Duong Bach, Pham The Hai, Vu Mai Thao, Nguyen Xuan Nhiem, Nguyen Hai Dang*, Cycloartane-type saponins from Curculigo orchioides and their anti-inflammatory activity, RSC Advances, 15, 41340-41350, 2025.
- Thanh Huong Le, Quang Huy Nguyen, Thu Hang Thi Le, Hoang Long Le, Quang Hieu Pham, Kieo Oanh Thi Nguyen, Hoang Nam Pham, Thanh Hoa Tran, Tan Khanh Nguyen, Manh Hung Tran, Hai Dang Nguyen*. Cytotoxic activity of Vietnamese Morus alba leaf compounds against human leukemia cells: In vitro and in silico evaluations. Rev. Bras. Farmacogn. 35, 968–980, 2025.
- Nguyen Quang Thai, Phan Thi Tu Uyen, Can Van Mao, Nguyen Hai Dang, Han Bo, Hoang Xuan Ba. Synergistic anti-tumor effect of fenbendazole and diisopropylamine dichloroacetate in immunodeficient BALB/c nude mice transplanted with A549 lung cancer cells. Translational Lung Cancer Research,14 (7), 2509-2521, 2025
- Le Thanh Huong, Tran Tuan Anh, Nguyen Minh Hang, Vu Mai Thao, Nguyen Xuan Nhiem, Nguyen Hai Dang*, Stereochemical assignment of four monoterpene glucoside derivatives from Turpinia montana Kurz by NMR study combined with CD spectroscopy, Magnetic Resonance in Chemistry, 62(8), 629-635, 2024.
- Thi Thu Phuong Tran, Duong Thu Trang, Le Thanh Huong, Tran Huu Giap, Nguyen Thi Minh Hang, Nguyen Xuan Nhiem, Nguyen Hai Dang*, Chemical constituents from Memecylon scutellatum with Nitric oxide inhibitory activity, Natural Product Communications, 19(12), 2024.
- Tran Thi Thu Phuong, Nguyen Hai Dang*, Nguyen Thi Hong Anh, Do Hoang Giang and Nguyen Tien Dat, A new megastigmane glycoside and other constituents from Amomum muricarpum Elmer, Records of Natural Products, 17(1), 184-188, 2023.
- Le Thanh Huong, Tran Phuong Thao, Do Thi Trang, Jeong-Hyung Lee, Bui Huu Tai, Phan Van Kiem, Nguyen Xuan Nhiem, Nguyen Hai Dang*, Anti-osteoclastogenic cycloartane saponins from Mussaenda pubescens, Natural Product Research, 36(18), 4579-4604, 2022.
- Minju Gal, Okwha Kim, Phuong Thao Tran, Le Thanh Huong, Nguyen Xuan Nhiem, Phan Van Kiem, Nguyen Hai Dang* and Jeong-Hyung Lee, Mussaendoside O, a N-triterpene cycloartane saponin, attenuates RANKL-induced osteoclastogenesis and LPS-induced bone loss, Phytomedicine, 105, 154378, 2022.
- Le Thanh Huong, Minju Gal, Okwha Kim, Phuong Thao Tran, Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Nguyen Hai Dang* and Jeong-Hyung Lee, 23-Hydroxyursolic acid from Viburnum lutescens inhibits osteoclast differentiation in vitro and lipopolysaccharide-induced bone loss in vivo by suppressing c-Fos and NF-κB signaling, International Immunopharmacology, 111, 109038, 2022.
- Nguyen Hai Dang, Le Nguyen Thanh, Do Hoang Giang, Nguyen Tien Dat, Anti-Inflammatory Components from the Fruits of Amomum aromaticum, Records of Natural Products, 16(3), 236-241, 2022.
- Le Thanh Huong, Pham Anh Thu, Phi Thi Dao, Doan Thi Mai Huong, Pham Van Cuong, Nguyen Hai Dang*, Anti-Inflammatory properties of longifuran A, a new benzofuran from the stems of Amomum longiligulare, Chemistry and Biodiversity, 18, e202100518, 2021.
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